RIESGOS DE UN COMPUESTO QUÍMICO
El Bisfenol A: ¿Un problema de Salud Pública?
AUTORES
MANUEL JESÚS PÉREZ GIRÁLDEZ
SANTIAGO GRANDE BELTRÁN
ESTHER DEL CASTILLO QUESADA
VANESSA TORRES SAURA
MANUEL PÉREZ CAMPOS
LIDIA MARÍA BERNAL BOLAÑOS
Veterinario del Cuerpo Superior Facultativo de Instituciones Sanitarias (II.SS.) de la Junta de Andalucía.
Veterinario II.SS. Junta de Andalucía.
Farmacéutica II.SS. Junta de Andalucía.
Farmacéutica II.SS. Junta de Andalucía.
Estudiante de Medicina.
Licenciada en Farmacia.
2012-10-17
<p>(1) <em>Brede ,C. Increased migration levels of bisphenol A from polycarbonate baby bottles after dishwashing, boiling and brushsing. Food Addit Contam, 2003; 20 </em>(7): <em>684-689</em></p>
, editor_pressclip
<p>(2) <em>López Cervantes J, Paseiro Losada P. Determination of bisphenol A in, and its migration from, PVC stretch film used for food packaging. Food Addit Contam., 2003 Jun; 20 (6): 596-606.</em></p>
, editor_pressclip
<p>(3) <em>Muncke J. Exposure to endocrine disrupting compounds via the food chain: Is packaging a relevant source? Sci Total Environ.,2009 Aug 1;407(16):4549-59.</em></p>
, editor_pressclip
<p>(4) <em>Wagner M, Oehlmann J. Endocrine disruptors in bottled mineral water: total estrogenic burden and migration from plastic bottles. Environ Sci Pollut Res, 2009; 16:278v286.</em></p>
, editor_pressclip
<p>(5) <em>Von Saal FS, Welshons W. Large effects from small exposures.II. The importance of positive controls in low-dose research on bisphenol A. Environmental Research, Jan 2006; 110 (1): 50-76.</em></p>
, editor_pressclip
<p>(6) <em>Balakrishnan, B, K Henare, EB Thorstensen, AP Ponnampalam, MD Mitchell. Transfer of bisphenol A across the human placenta. American Journal of Obstetrics and Gynecology, 2010; 202:393e1-e7.</em></p>
, editor_pressclip
<p>(7) <em>Olea, N. II Congreso Internacional de Medicina Ambiental. Brunete, Junio 2008</em></p>
, editor_pressclip
<p>(8) <em>Fernández MF, Arrebola JP, Taoufiki J, Navalón A, Ballesteros O, Pulgar R, Vilchez JL, Olea N. Bisphenol- A and chlorinated derivatives in adipose tissue of women. Reproductive Toxicology, 2007; 24(2):259-64.</em></p>
, editor_pressclip
<p>(9)<em>Takada et al. Bisphenol A and nonylphenols in human umbilical cords. Proceedings of the International Scientific Conference on Environmental Endocrine Disrupting Chemicals. Monte Verita, Ascona (Suiza). 7-22 March 1999.</em></p>
, editor_pressclip
<p>(10) <em>Schonfelder et al. Parent bisphenol A accumulation in the human maternal-fetal-placental unit. Environmental<br />
Health Perspectives, 2002; 110 (11) 703-707.</em></p>
, editor_pressclip
<p>(11)<em>Takai et al. Estrogen receptor-mediated effects of a xenoestrogen , bisphenol-A, on preimplantation mouse embyos. Biochem Biophys Res Commun, 2000; 270 (3): 918-921.</em></p>
, editor_pressclip
<p>(12) <em>Takai et al. Preimplantation exposure to bisphenol A advances postnatal development. Reprod Toxicol, 2001 ; 15 (1): 71-74).</em></p>
, editor_pressclip
<p>(13) <em>Ben-Jonathan N, Hugo ER, Brandebourg TD. Mol Cell Endocrinol., 2009 May 25; 304(1-2):49-54.</em></p>
, editor_pressclip
<p>(14) <em>Mivawaki J, Sakayama K, Kato H, Yamamoto H, Masuno H. Perinatal and postnatal exposure to bisphenol a increases adipose tissue mass and serum cholesterol level in mice. J Atheroscler Thromb., 2007 Oct; 14(5):245-52.</em></p>
, editor_pressclip
<p>(15) <em>Lang Al et al (2008) Associattion of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. Journ Am Med Assoc, 2008; 300 (11) 1303-1310.</em></p>
, editor_pressclip
<p>(16)<em>Varayoud J, Ramos JG, Bosquiazzo VL, Muñoz-de- Toro M, Luque EH. Developmental exposure to Bisphenol A impairs the uterine response to ovarian steroids in the adult. Endocrinology. 2008 Nov; 149(11):5848-60.</em></p>
, editor_pressclip
<p>(17) <em>Lee YM, Rhee JS, Hwang DS, Kim IC, Raisuddin S, Lee JS. p53 gene expression is modulated by endocrine disrupting chemicals in the hermaphroditic fish, Kryptolebias marmoratus. Comp Biochem Physiol C Toxicol Pharmacol., 2008 Mar; 147(2):150-7. </em></p>
, editor_pressclip
<p>(18) <em>Vandenberg LN, Maffini MV, Schaeberle CM, Ucci AA, Sonnenschein C, Rubin BS, Soto AM. Perinatal exposure to the xenoestrogen bisphenol-A induces mammary intraductal hyperplasias in adult CD-1 mice. Reprod Toxicol., 2008 Nov-Dec; 26 (3-4):210-9.</em></p>
, editor_pressclip
<p>(19) <em>Izzotti A, Kanitz S, D'Agostini F, Camoirano A, De Flora S Formation of adducts by bisphenol A, an endocrine disruptor, in DNA in vitro and in liver and mammary tissue of mice. Mutat Res., 2009 Sep-Oct;679(1-2):28-32.</em></p>
, editor_pressclip
<p>(20) <em>Markey CM, Luque EH, Munoz De Toro M., Sonnenschein C, Soto, AM. In utero exposure to bisphenol A alters the development and tissue organization of the mouse mammary gland. Biol. Reprod., 2001; 65: 1215v1223.</em></p>
, editor_pressclip
<p>(21) <em>Ho S-M, Tang W-Y, Belmonte de Frausto J, Prins GS. Developmental Exposure to Estradiol and Bisphenol A Increases Susceptibility to Prostate Carcinogenesis and Epigenetically Regulates Phosphodiesterase Type 4 Variant 4. Cancer Res., 2006 June 1; 66: 5624.</em></p>
, editor_pressclip
<p>(22) <em>A.Keri RA, Ho SM, Hunt PA, Knudsen KE, Soto AM, Prings GS. An evaluation of evidence for the carcinogenic activity of bisphenol. Reprod Toxicol., 2007 Aug- Sep; 24(2):240-52</em></p>
, editor_pressclip
<p>23) <em>Soto AM, Maffini MV, Sonnenschein C . Neoplasia as development gone awry: the role of endocrine disruptors. Int J Androl. 2008 Apr;31(2):288-93.</em></p>
, editor_pressclip
<p>(24) <em>Tayama S, Nakagawa Y, Tayama K. Genotoxic effects of environmental estrogen-like compounds in CHO-K1 cells. Mutat Res., 2008 Jan 8;649(1-2):114-25.</em></p>
, editor_pressclip
<p>(25) <em>Matsushima A, Kakuta Y, Teramoto T, Koshiba T, Liu X, Okada H, Tokunaga T, Kawabata SI, Kimura M, Shimohigashi Y. Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma. J Biochem. 2007 Oct;142(4):517-24.</em></p>
, editor_pressclip
<p>(26) <em>Yamada et al (2002). Maternal serum and amniotic fluid bisphenol A concentrations in the early second trimester. Reprod Toxicol, 2002; 16 (6): 735-739.</em></p>
, editor_pressclip
<p>(27)<em> Howdeshell KL et al. Exposure to bisphenol A advances puberty. Nature, 1999; 401 (6755): 763-764.</em></p>
, editor_pressclip
<p>(28)<em> Takeuchi T y Tsutsumi O. Serum bisphenol A concentrations showed gender differences, possibly linked to androgen levels. Biochem Biophys Res Commun, 2002; 291 (1): 76-78.</em></p>
, editor_pressclip
<p>(29)<em> Ikezuki Y, Tsutsumi O, Takail Y, Kamei, Y, Taketani, Y. Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure. Human Reprod, 2002; 17: 2839-2841.</em></p>
, editor_pressclip
<p>(30) <em>Li De-K, Zhou Z, Miao M, He Y, Wang J, Ferber J,. Herrinton L Gao E, Yuan W. Urine bisphenol-A (BPA) level in relation to semen quality. Fertility and Sterility, February 2011; 95(2): 625-630.</em></p>
, editor_pressclip
<p>(31) <em>Ishido M, Yonemoto J, Morita M. Environmental Risk Research Program, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba 305-8506, Japan.</em></p>
, editor_pressclip
<p>(32) <em>Huang H, Leung LK. Bisphenol A downregulates CYP19 transcription in JEG-3 cells. Toxicol Lett. 2009 Sep 28;189(3):248-52.</em></p>
, editor_pressclip
<p>(33) <em>Pattishall AE, Spector ND. Endocrine disruptors, travel- associated illness, and media violence: important health considerations for children and adolescents. Curr Opin Pediatr. 2010 Oct 20.</em></p>
, editor_pressclip
<p>(34) <em>Vom Saal FS, Myers JP. Bisphenol A and risk of metabolic disorders. JAMA, 2008; 300 (11): 1353- 1355.</em></p>
, editor_pressclip
<p>(35) <em>Opinión de la EFSA en relación al BPA Question number: EFSA-Q-2009-00864 , EFSA-Q-2010-00709 , EFSA-Q-2010-01023 Adopted: 23 September 2010</em></p>
, editor_pressclip